What is it about?

Specialized monocytes with patrolling behavior, which are termed Ly6C lo monocytes, are recruited to sites of arterial injury and promote endothelial proliferation. The recruitment of these cells is coordinated by a cell-bound chemokine, called Fractalkine (CX3CL1), which recruits these cells its cognate receptor CX3CR1.

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Why is it important?

Endothelial cells require monocytes to close arterial wounds in arteries

Perspectives

Specialized monocytes might be agents for cell-based therapies to repair injured arteries

Florian Limbourg
Medizinische Hochschule Hannover

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This page is a summary of: The chemokine receptor CX 3 CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury , EMBO Molecular Medicine, December 2017, EMBO,
DOI: 10.15252/emmm.201707502.
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