What is it about?
dihydroceramide; lipophagy; neurodegeneration; photoreceptors; sphingolipid
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Why is it important?
This study demonstrates a novel requirement for dhCer desaturase in neuronal maintenance in vivo and shows that lipophagy activation prevents activity-dependent degeneration caused by dhCer accumulation.
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Lipophagy prevents activity‐dependent neurodegeneration due to dihydroceramide accumulation
in vivo
, EMBO Reports, May 2017, EMBO,
DOI: 10.15252/embr.201643480.
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