What is it about?
IkBa interacts with VDAC and hexokinase 2 at mitochondria to prevent cytochrome c release and apoptosis of tumor cells, independently of its function as an NF‐κB inhibitor. IkBa resides at the outer mitochondrial membrane. IkBa associates with VDAC1 and hexokinase 2 to inhibit the dissociation of HK2. IkBa prevents Bax‐mediated cytochrome c release for apoptosis induction. This novel anti‐apoptotic activity of IkBa is independent of NF‐kB retention.
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Why is it important?
This study is important because it uncovers a previously unappreciated role of IkBa and opens new study hypothesis for cancer and neurodegenerative diseases.
Read the Original
This page is a summary of: IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention, The EMBO Journal, October 2014, EMBO,
DOI: 10.15252/embj.201488183.
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