What is it about?
Synthesis of novel organophosphorus and heterocyclic structures using organophosphorus reagents and their biological activities.
Featured Image
Why is it important?
The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with several classes of organophosphorus reagents: phosphonium ylides, Wittig-Horner reagents, dialkylphosphonates, trialkylphosphites, tris(dialkylamino)phosphanes, triphenylstibane, triphenylarsane, and Lawesson’s reagent are reported. Structural reasoning for the new products was based on compatible analytical and spectral data. The cytotoxic activity of most of the new products was evaluated against human breast carcinoma cell line (MCF7) and human hepatocellular carcinoma cell line(HepG2). Certain tested compounds showed promising results
Perspectives
Azidopyrazole derivatives are very reactive starting material for preparation new organophosphorus structures and promising heterocylic compounds.
Dr. Naglaa F. El-Sayed
National Research Centre
Read the Original
This page is a summary of: Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities, Zeitschrift für Naturforschung B, July 2016, De Gruyter,
DOI: 10.1515/znb-2015-0187.
You can read the full text:
Contributors
The following have contributed to this page
