new reagents for acylation of amines in water

What is it about?

Acylation of amines is of enormous interest in organic synthesis since it provides a useful and efficient protection protocol in a multistep synthesis process. In this work, the synthesis of a series of new acylating reagents, which are useful for the chemoselective acylation of amino groups of compounds which possess both amino and other acylatable groups in water.

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Why is it important?

Selective protection of primary amines in the presence of secondary amines, acylation of aliphatic amines in the presence of aryl amines and monofunctionalization of primary-secondary diamines as well as selective N-acylation of aminoalcohols using these reagents is described. All of the acylation reactions were carried out in water as a green solvent. High stability and easy preparation of these acylating reagents are other advantages of this method.