What is it about?
In this study, protein drug interactions were investigated using 5-Fluorouracil anti-cancer drug and human serum albumin protein.
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Why is it important?
The results of this study indicated that 5-FU had a weak association with albumin, and it easily dissociated from the protein to which it was attached.The obtained results also gave us useful information about molecular dynamics of drug-albumin interactions.
Perspectives
Human serum albumin (HSA) is often selected as a subject of any study because albumin is the most abundant protein in human blood plasma. NMR is recognized as a valuable method to determine the structure of proteins-ligand and protein-drug complexes.
Sibel Korunur
Munzur Universitesi
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This page is a summary of: Investigation of relaxation times in 5-fluorouracil and human serum albumin mixtures, Turkish Journal of Biochemistry, August 2019, De Gruyter,
DOI: 10.1515/tjb-2017-0363.
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