What is it about?
Harmonisation of immunoassays is not satifactory in our field yet, so reference intervals are still specific for the current measurement system.
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Why is it important?
Especially congenital hypothyroidism is a preventable disorder, and the blood TSH & FT4 levels of newborns or subjects of early childhood should be evaluated properly in clinical decision.
Perspectives
Although estimation via indirect reference intervals has not been recommended by IFCC, blood sampling and ethical issues, especially for early childhood, drive us prefering accumulated data in establishing reference intervals specific for the immunoassay methodology.
Hale Aral
Ministry of Health, Turkish Republic
Read the Original
This page is a summary of: Pediatric reference intervals of free thyroxine and thyroid stimulating hormone in three different hospitals, Turkish Journal of Biochemistry, January 2018, De Gruyter,
DOI: 10.1515/tjb-2017-0342.
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