Tthe enantioselective production of (R,S)-2-pentanol.

What is it about?

Enantiomeric compounds can cause different biological effects, thus it is so important to use pure enantiomer in the drugs.S-2-pentanol is a key chiral intermediate required in the synthesis of several potential anti-Alzheimer drugs that inhibit β-amyloid peptide release or synthesis

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Why is it important?

We defined the effects of enzyme source, type of acyl donor, amount of alcohol, amount of enzyme, and acyl donor/alcohol mole ratio, high substrate concentration on the enantiomeric excess of the substrate (eeS) and initial reaction rate for S-2-pentanol . Secondly, internal and external mass transfer limitations were determined and estimation of the kinetic modeling was performed in the batch heterogen bioreactor system. Thus, in order to produce enantio pure S-2-pentanol with continuous process, the basic knowledege were obtained.

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