Gilbert's Syndrome: A Possible Protective Effect On Endothelial Dysfunction

What is it about?

Previously published several studies have shown that low serum bilirubin predicts future cardiovascular disease and increased bilirubin level promotes protection against oxidative stress-mediated diseases, especially atherosclerotic diseases particularly in men. Although elevated serum bilirubin concentrations may protect against endothelial dysfunction, the mechanisms of decreased frequency of atherosclerotic disease in GS are not entirely known but probably multifactorial. In the present study, we aimed to assess circulating levels of asymmetric dimethylarginine, pentraxin-3 and high sensitivity C-reactive protein between patients with GS and controls and determine the correlation of unconjugated bilirubin levels with these molecules as prognostic factors for vascular risk stratification and subclinical atherosclerosis.

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Why is it important?

The present study showed for the first time that subjects with Gilbert's Syndrome have slightly decreased asymmetric dimethylarginine, pentraxin-3 and high sensitivity C-reactive protein values compared to healthy controls.