What is it about?
To evaluate the physico-chemical stability of concentrated solution of noradrenaline bitartrate in polypropylene syringe during 30 days at 5 ± 3°C .
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Why is it important?
All solutions were physico-chemically stable during the whole period storage at 5 ± 3°C: no color change, turbidity, precipitation or opacity, no significant pH variations or optic densities were observed in the solutions. Any crystals were seen by microscopic analysis. The concentration of noradrenaline was not found to decrease during the 30 days of storage
Perspectives
Solutions of noradrenaline bitartrate 0.240 mg/ml in syringe of 0.9 % NaCl are physically and chemically stable for at least 30 days when stored in syringes at 5 ± 3°C and may be prepared in advanced by a centralized intravenous additive service (CIVAS).
Professor Jean-Daniel HECQ
CHU UCL Namur, Belgium
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This page is a summary of: Stability of Concentrated Solution of Vancomycin Hydrochloride in Syringes for Intensive Care Units, Pharmaceutical Technology in Hospital Pharmacy, March 2018, De Gruyter,
DOI: 10.1515/pthp-2017-0031.
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