What is it about?
In major or major-plus elective surgical interventions for gastrointestinal tumors were scored using the modified POSSUM mortality risk analysis. Postoperative neopterin, IL-6 and albumin are signifcantly dependent on the predicted mortality rates according to the newly designed POSSUM scoring system.
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Why is it important?
In patients undergoing major surgery for gastrointestinal tumors, post-operative systemic inflammatory response syndrome and sepsis are associated with high morbidity and mortality due to the presence of dense bacterial flora in the gastrointestinal tract. Therefore, some immunological variables may be reliable predictors of post-operative systemic inflammatory response syndrome. Therefore, this study revealed that post-operative albumin, post-operative IL-6 and post-operative neopterin concentrations were indispensable variables in establishing the individual accuracy of POSSUM predictive mortality.
Perspectives
The assessment of metabolic and immune responses during the risk adjustment and stratification of patients with gastrointestinal tumor surgery will increase the quality assurance of this scoring system.
Atilla Engin
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This page is a summary of: Perioperative Mortality Prediction Using Possum in Patients with Gastrointestinal Tumors: Do Immunological Variables Affect Individual Predictive Mortality Risk?, Pteridines, October 2018, De Gruyter,
DOI: 10.1515/pteridines-2018-0012.
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