What is it about?
New bismuth(III) bromine compounds of the heterocyclic thioamides were prepared and structurally characterized. Complexes were evaluated in terms of their in vitro cytotoxic activity against human adenocarcinoma breast (MCF-7) and cervix (HeLa) cells. The toxicity on normal human fetal lung fibroblast cells (MRC-5) was also evaluated. Moreover, the complexes and free heterocyclic thioamide ligands were studied upon the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX).
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Why is it important?
Five novel bismuth(III) bromide complexes with heterocyclic thioamide ligands have been successfully synthesized and characterized. The molecular structures of complexes are isostructural. These are the first examples of dinuclear bismuth(III) bromide compounds that have been structurally characterized with square pyramidal (SP) conformation around the metal center.
Perspectives
This article is the result of long-term cooperation and it is the collaboration of scientists from four different countries. I hope this article is useful for other scientists.
Ibrahim Ismet OZTURK
Namık Kemal University
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This page is a summary of: Bismuth(III) bromide-thioamide complexes: synthesis, characterization and cytotoxic properties, Main Group Metal Chemistry, November 2018, De Gruyter,
DOI: 10.1515/mgmc-2018-0035.
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