What is it about?
This is a two-arm prospective study on screening for Down's syndrome. According to the available knowledge this is the first study to compare combined screening vs ultrasound-based screening based on the total group of 10 878 pregnant women.
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Why is it important?
The study results are a strong argument to re-discuss the CST effectiveness, especially in terms of false-positive results.
Perspectives
Currently, the strategy of contingent screening using the combined screening as an initial method supplemented with high sensitivity NIPT tests is being discussed in the literature. In our assessment, the multi-parameter ultrasound test would have at this point a more appropriate preliminary role due to the greater specificity and independence from biomarkers which are influenced by a number of factors in the body of the pregnant.
Dr. Marcin Wiechec
Jagiellonian University in Krakow
Read the Original
This page is a summary of: Combined screening test for trisomy 21 – is it as efficient as we believe?, Journal of Perinatal Medicine, January 2017, De Gruyter,
DOI: 10.1515/jpm-2016-0031.
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