What is it about?
mutations of profilin-1 associated with familal amyotrophic lateral sclerosis are able to unfold the native state of profilin-1
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Why is it important?
it establishes the mechanism of action by which mutations of profilin-1 causes familial amyotrophic lateral sclerosis associated with the prfilin-1 gene
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This page is a summary of: Biophysical analysis of three novel profilin-1 variants associated with amyotrophic lateral sclerosis indicates a correlation between their aggregation propensity and the structural features of their globular state, Biological Chemistry, September 2016, De Gruyter,
DOI: 10.1515/hsz-2016-0154.
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