What is it about?
Chaperones do not just aid protein folding and prevent protein aggregation. They also protect protein aggregates after they are formed and they decrease their toxicity
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Why is it important?
This analysis is important because it illustrates the mechanism of action of chaperones on oligomers when the former are aobve or below the concentrations of the latter.
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This page is a summary of: Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations, Biological Chemistry, January 2016, De Gruyter,
DOI: 10.1515/hsz-2015-0250.
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