What is it about?
Preparing Schiff base ligands containing quinoline moiety and their metal complexes. We have investigated their in vitro microbial activities and studied in silico their physicochemical and pharmacokinetics properties. The in silico pharmacokinetics predictions showed that the ligands have high gastrointestinal (GI) absorption and the complexes showed low GI absorption. The ligands showed a good bioavailability score where the complexes showed moderate to poor bioavailability.
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Why is it important?
Preparation of new ligands and used them for preparation of some metal complexes. The metal complexes showed enhancement in microbial activity. Compounds in general were moderately active against Gram-positive bacterial strains and inactive against the gram-negative bacterial strains and the fungal strains.
Perspectives
It is recommended to develop more new ligands based on quinoline core and may use them for synthesis of pharmaceuticaly important complexes.
Smi Zabin
Albaha University
Read the Original
This page is a summary of: New Schiff bases of 2-(quinolin-8-yloxy)acetohydrazide and their Cu(ii), and Zn(ii) metal complexes: their in vitro antimicrobial potentials and in silico physicochemical and pharmacokinetics properties, Open Chemistry, June 2020, De Gruyter,
DOI: 10.1515/chem-2020-0085.
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