What is it about?
In a classical bone healing model TNF-α is produced by hematoma recruited macrophages and inflammatory cells, which in turn stimulate periosteal osteoblasts to secrete BMP-2 for bone induction. However specific macrophages, as first cells, appear to colonize a titanium implant directly in the absence of osteoblasts. This is supported by findings (i) that "healing macrophages" (M2), also called "osteomacs", are residents of bone, (ii) that such macrophages and not osteoblasts are the initial secretors of BMP-2, and (iii) that nanostructure size on implant surfaces correlates with BMP-2 production by macrophages in culture. Together with results in minipigs a model is proposed, in which initially colonizing macrophages on an implant surface initiate the osseointegration of that implant by BMP-2 secretion.
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Why is it important?
A macrophage based model of osseointegration provides a new approach to the synthesis of osteophilic i.e. "macrophage customized" implant surfaces.
Perspectives
Ideas, perspectives and models stimulate and direct research. Maybe this paper will be helpful to groups working in the area of improving biomaterial and implant surfaces for the better of patients.
Prof. Dr. Herbert Jennissen
Universitat Duisburg-Essen
Read the Original
This page is a summary of: A macrophage model of osseointegration, Current Directions in Biomedical Engineering, January 2016, De Gruyter,
DOI: 10.1515/cdbme-2016-0015.
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