Clinical vs. statistical significance: considerations for clinical laboratories

What is it about?

This paper discusses statistical inference and its relevance to clinical importance in quantitative testing in clinical laboratories. To achieve this, we first pose questions focusing on fundamental statistical concepts and their relationship to clinical significance. The paper also aims to provide examples for using the methodological approaches of superiority, equivalence, non-inferiority, and inferiority studies in clinical laboratories, which can be used in evidence-based decision-making processes for laboratory professionals.

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