Predicting the protective humoral response to a SARS-CoV-2 mRNA vaccine

What is it about?

Antibody response was evaluated by a quantitative anti-SARS-CoV-2 RBD IgG commercial assay and by virus microneutralization test (MNT), in order to establish a threshold of anti-RBD binding antibody units (BAU) able to predict a robust (≥1:80) MNT titre in vaccinated HCW and in COVID-19 recovered patients. A threshold of 2,000 BAU/mL is highly predictive of strong MNT response in vaccinated individuals and may represent a good surrogate marker of protective response.

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