Human chorionic gonadotropin suspected heterophile interference investigations in immunoassays: a recommended approach

What is it about?

Heterophile antibody (HAb) interferences in immunoassays can cause falsely elevated hCG concentrations leading to incorrect diagnosis and treatments options. The use of heterophile blocking reagents failed to detect ~40% of cases. Blocking reagents should not solely be used for these investigations. Multiple strategies including the use of serial dilutions and using an alternative platform are critical when troubleshooting interferences in the hCG assay.

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