Response to Letter to the Editor about immunochemical measurement of urine free light chains

What is it about?

Further information is required before nephelometric urinary free light chains (FLC) assays can be introduced into clinical practice namely: a. What is the need to measure FLC in urine by immunoassay when serum FLC measurement has undergone extensive clinical and laboratory validation? b. A study to assess the specificity of urine FLC assay is required, that is, how many ‘false positives’ are produced in patients without monoclonal gammopathies? At present it is premature to conclude that "nephelometric urinary FLC assays provide an alternative clinical test for Bence Jones protein quantification".

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