What is it about?
This review is aimed at describing the most recent evidence about the utility of faecal calprotectin (FCAL) in the management of inflammatory bowel diseases, including diagnosis, assessment of disease activity and mucosal healing, response to therapy, and capacity to predict relapse and postoperative recurrence. These aspects are viewed with a special focus on systematic reviews with meta-analyses carried out for each purpose. We also reviewed the reported differences between the several FCAL assays available in clinical practice, as this is one of the main hurdles for its clinical implementation. Finally, current limitations of FCAL in clinical settings and other alternative biomarkers are discussed.
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Why is it important?
Our review represents the first comprehensive revision of FCAL performance in inflammatory bowel diseases (IBD) by providing a special focus on meta-analyses jointly with the pooled sensitivity and specificity values estimated on them. Therefore, our review covers a complete picture of FCAL usage for the whole clinical management of patients with IBD and provides a different point of view compared to previous reviews on the field. Describing also the limitations of FCAL measurement could be also valuable for laboratory and clinical professionals to understand the disagreement and controversy of certain aspects of FCAL implementation.
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This page is a summary of: Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations, Clinical Chemistry and Laboratory Medicine (CCLM), August 2019, De Gruyter,
DOI: 10.1515/cclm-2018-1063.
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