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Enzymatic methods are analytically superior as compared to the traditional Jaffe method. Plasma proteins and glucose are known to interfere with Jaffe assays. Despite their analytical superiority, enzymatic creatinine methods do not warrant a reliable estimation of kidney function in severely ill patients. As an alternative, mathematical corrections of creatinine results or clearance of exogenous substances should be considered for estimating kidney function in severely ill patients.

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This page is a summary of: Interference of glucose and total protein on Jaffe-based creatinine methods: mind the covolume, Clinical Chemistry and Laboratory Medicine (CCLM), July 2018, De Gruyter,
DOI: 10.1515/cclm-2018-0192.
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