What is it about?
The circulating level of the peptide hormone insulin-like factor 3 (INSL3) is a promising diagnostic marker in male subjects with andrological and developmental disorders. We have developed a robust and sensitive method suitable for quantitation of serum INSL3 in a clinical setting using LC-MS/MS instrumentation available in modern clinical laboratories. The method paves the way for future studies into the clinical role of serum INSL3 measurements.
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Why is it important?
The new assay paves always for clinical studies of serum INSL3 and will aid in defining the diagnostic role of serum INSL3 meausurements.
Perspectives
Identifying the diagnostic role of INSL3 is likely difficult and probably requires studies of patients during and after treatment in order to pinpoint the subgroup of individuals that may possibly benefit from INSL3 measurements. The presented assay make such clinical studies feasible.
Jakob Albrethsen
Rigshospitalet
Read the Original
This page is a summary of: Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum, Clinical Chemistry and Laboratory Medicine (CCLM), October 2018, De Gruyter,
DOI: 10.1515/cclm-2018-0171.
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