What is it about?
This opinion paper is to clarify the use of the terms validation and verification of reference intervals, to describe the CLSI recommendations for verifying reference intervals, to discuss the development of currently available reference intervals, to describe the transferring/verifying processes of reference intervals obtained from multicenter studies, to introduce alternative verification methods, to discuss challenges for reference intervals establishment/verification in pediatric and geriatric populations and, ultimately, to encourage routine laboratories to verify reference intervals.
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Why is it important?
The verification of reference intervals is an important and challenging issue for the routine clinical laboratories. Although procedures for verifying reference intervals in the literature and guidelines are clear in theory, gaps remain for the implementation of these procedures in routine clinical laboratories. We reviewed the current guidelines/approaches and challenges to reference interval verification and provide a practical guide for routine implementation in clinical laboratories.
Perspectives
Writing this article was a great pleasure as it has co-authors with who are working for the Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER) that aims to improve paediatric diagnostic care by establishing accurate reference intervals for important laboratory tests. This article also lead to the laboratory specialists contacting me and ultimately, to encourage routine laboratories to verify of reference intervals.
Yesim Ozarda
Uludag Universitesi
Read the Original
This page is a summary of: Verification of reference intervals in routine clinical laboratories: practical challenges and recommendations, Clinical Chemistry and Laboratory Medicine (CCLM), May 2018, De Gruyter,
DOI: 10.1515/cclm-2018-0059.
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