What is it about?
Programmed ribosomal frameshift (PRF) occurs at certain mRNA to generate alternative translation products from same mRNA. Previously it was thaugt that PRF is a constitutive event that takes place at certain rate depending on mRNA species. This study provides significant data that PRF can be regulated depending on growth conditions of the cell.
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Why is it important?
Programmed ribosomal frameshift (PRF) provides alternative recoding of mRNA sequencing in certain mRNA species. In EST3 mRNA that encodes one of the telomerase subunit, translation of Est3 peptides terminated early at internal stop codon, which generates non functional, truncated peptides. However, upon PRF at +1 direction at the internal stop codon, ribosomes continues to translation and generates full, lenght functional Est3 peptides that function in telomerase replication. Our results indicates that PRF event at EST3 mRNA is regulated depending on stress conditions
Perspectives
We hope that this study provides a nice example for the regulation of PRF depending on growth conditions. It may also applicable for the regulation of translation elongation in response to growth conditions.
Professor Sezai Türkel
Uludag University
Read the Original
This page is a summary of: Effects of stress activated protein kinases on the expression of EST3 gene that encodes telomerase subunit in Saccharomyces cerevisiae, Biologia, January 2017, De Gruyter,
DOI: 10.1515/biolog-2017-0039.
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