What is it about?
The possible increased risk of deep vein thrombosis (DVT) or recurrent pregnancy loss (RPL) can be result from thrombogenic gene mutations. We determined Factor V Leiden, Prothrombin, and Methylenetetrahydrofolate reductase gene mutations as molecular markers in evaluation of venous thrombosis and recurrent pregnancy loss
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Why is it important?
Our findings show that high frequency of heterozygous factor V Leiden mutation G/A genotype is significantly associated with DVT. Prothrombin G20210A and MTHFR C677T mutations had a lower impact on the risk of DVT and RPL.
Perspectives
We hope that the article launched valuable informative data for prediction of genetic predisposing likely to be occurs among high risk individuals, which facilitate diagnosis and patients management
mahmoud abdalla
Read the Original
This page is a summary of: Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss, Open Life Sciences, May 2017, De Gruyter,
DOI: 10.1515/biol-2017-0019.
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