SSTR4, childhood adversity, self-efficacy and suicide risk in alcoholics

  • Dominika Berent, Gerard Emilien, Michał Podgórski, Ewa Kusideł, Dominika Kulczycka-Wojdala, Bożena Szymańska, Marian Macander, Zofia Pawłowska
  • Translational Neuroscience, September 2017, De Gruyter
  • DOI: 10.1515/tnsci-2017-0013

SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics. Berent D et al.

What is it about?

Patients with alcohol dependence (AD) are known to develop poor social skills, to report a higher number of adverse childhood experiences (ACEs) and to attempt suicide more frequently than the general population. The background for the association between ACEs and a higher risk of suicide still remains understudied. SSTR4 rs2567608 is a functional polymorphism of the gene for somatostatin receptor subtype 4, predominantly found in the CA1 hippocampus area and involved in memory formation. We hypothesize that the functional polymorphism SSTR4 rs2567608, general self-efficacy, and adverse childhood experiences influence the risk of suicide attempt in patients with AD.

Why is it important?

Our study supports previous findings on ACEs and general self-efficacy association with a risk for suicide. Additionally, we suggest that patients with AD of the SSTR4 rs2567608 TT genotype may be more vulnerable to ACEs and at a higher risk of suicide attempt.

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http://dx.doi.org/10.1515/tnsci-2017-0013

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