What is it about?
Hesperidin and Vitamin E ameliorated cardiac injury induced by doxorubicin (Dox) as indicated by decreasing LDH and CK activities as well as lessening histopathological alteration. Hesperidin and Vitamin E alleviate oxidative stress induced by Dox as evident from the decreased cardiac MDA and serum NO levels and cardiac catalase and serum MPO activity. Hesperidin and Vitamin E act as detoxifying agents as indicated by increasing serum AE and PON activities and cardiac GSH level. Hesperidin and Vitamin E decrease apoptotic tissue damage as manifested by the decreased cardiac caspase 3 activity.
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Why is it important?
Natural compounds can be used in combination with chemotherapeutic agents to increase their effectiveness.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long-standing collaborations. This article also lead to cancer drug discovery groups contacting me and ultimately to greater involvement in their research.
Thoria Donia
Read the Original
This page is a summary of: Ameliorating oxidative stress and inflammation by Hesperidin and vitamin E in doxorubicin induced cardiomyopathy, Turkish Journal of Biochemistry, September 2018, De Gruyter,
DOI: 10.1515/tjb-2018-0156.
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Resources
Antioxidant effect of hesperidin isolated from orange peels
Egyptian citrus peels are a rich source of the antioxidant hesperidin.
Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice.
Egyptian citrus peels are a rich source of the antioxidant hesperidin. Moreover, it can ameliorate the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.
Contributors
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