What is it about?

Hesperidin and Vitamin E ameliorated cardiac injury induced by doxorubicin (Dox) as indicated by decreasing LDH and CK activities as well as lessening histopathological alteration. Hesperidin and Vitamin E alleviate oxidative stress induced by Dox as evident from the decreased cardiac MDA and serum NO levels and cardiac catalase and serum MPO activity. Hesperidin and Vitamin E act as detoxifying agents as indicated by increasing serum AE and PON activities and cardiac GSH level. Hesperidin and Vitamin E decrease apoptotic tissue damage as manifested by the decreased cardiac caspase 3 activity.

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Why is it important?

Natural compounds can be used in combination with chemotherapeutic agents to increase their effectiveness.

Perspectives

Writing this article was a great pleasure as it has co-authors with whom I have had long-standing collaborations. This article also lead to cancer drug discovery groups contacting me and ultimately to greater involvement in their research.

Thoria Donia

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This page is a summary of: Ameliorating oxidative stress and inflammation by Hesperidin and vitamin E in doxorubicin induced cardiomyopathy, Turkish Journal of Biochemistry, September 2018, De Gruyter, DOI: 10.1515/tjb-2018-0156.
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