Exploring evolutionary trajectories in ovarian cancer patients by longitudinal analysis of ctDNA

What is it about?

In ovarian cancer, the representation of evolutionary trajectories in the liquid biopsy and its potential clinical implications are unknown. We demonstrate that the analysis of circulating tumor DNA (ctDNA) in longitudinal plasma samples could be a promising tool for deciphering evolutionary trajectories in ovarian cancer patients. Moreover, we describe two different evolutionary patterns that may help to identify relapse seeding clones for targeted therapy.

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