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The biomarker [-2]proPSA outperforms free/total (f/t) PSA ratio in prostate cancer diagnosis. We examined [-2]proPSA stability over time in whole blood before separation of serum and plasma and its implications for Phi determination. EDTA prevented spurious in vitro modifications in PSA-related isoforms, confirming that a stabilized blood sample is a prerequisite for [-2]proPSA levels measurement and Phi determination.

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This page is a summary of: Preanalytical stability of [-2]proPSA in whole blood stored at room temperature before separation of serum and plasma: implications to Phi determination, Clinical Chemistry and Laboratory Medicine (CCLM), September 2018, De Gruyter,
DOI: 10.1515/cclm-2018-0596.
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