A specific abnormal scattergram of peripheral blood leukocytes that may suggest hairy cell leukemia

What is it about?

In this case-report, we describe our experience with the XN-module automated analyzer with WPC channel in investigating a case that was later diagnosed as hairy cell leukemia (HCL) by immunophenotypic and cytogenetic analysis.The CBC revealed a trilinear pancytopenia without any morphological flags nor in WDF channel nor in WPC channel but it showed abnormal WDF, WNR and WPC scattergrams. The optical microscopy review showed a complete lack of monocytes and the presence of some hairy cells. Data presented in this case-report suggest the hypothesis that the presence of an abnormal lymphocyte cell cluster distribution in WDF, WNR and WPC scattergrams, is likely to be representative of a pathological blood condition to be further evaluated by the hemopathologist with an accurate OM smear review, as a clue to the diagnosis of hairy cell leukemia

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