What is it about?

Pulmonary hypertension is one of the most risk factor of mortality in adults with sickle cell disease. Causes and management of this complication is still under debate. We have shown that pulmonary embolism increases the risk of elevated tricuspid regurgitation velocity (TRV ≥ 3.0 m/sec) in patients with sickle cell disease. These findings will help us to better classify and treat pulmonary hypertension is sickle cell patients.

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Why is it important?

Understanding the role of thromboembolic events in pulmonary hypertension of sickle cell disease will change the treatment and outcome of patients.


It was an analysis from two independent cohorts. It required tight collaboration between two cohorts. It was a very important experience for me.

Seyed Mehdi Nouraie
University of Pittsburgh Medical Center Health System

Read the Original

This page is a summary of: Potential Contribution of Pulmonary Thromboembolic Disease in Pulmonary Hypertension in Sickle Cell Disease, Annals of the American Thoracic Society, March 2020, American Thoracic Society,
DOI: 10.1513/annalsats.201911-840rl.
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