What is it about?
We investigated for the first time the molecular and functional characteristics of voltage‐gated proton channel (Hv1/VSOP) in zebrafish neutrophils. We also found that zebrafish Hv1, unlike its mammalian orthologs, is less sensitive to zinc ion. This phenomenon appears to be correlated with high concentration of zinc in blood serum of zebrafish.
Featured Image
Why is it important?
The study of DrHv1 spotlights the biological variation in diverse animal species and illustrates the power of zebrafish as the excellent in vivo model for studying the physiological function of Hv1 in the living animal.
Perspectives
This study is a foundation for understanding the functions of the voltage-gated proton channel (Hv1) in the physiological context. Based on these findings, we can proceed to investigate Hv1 in vivo by using zebrafish as the animal model - to see how Hv1 influences the physiological processes inside the living animal.
Dr Adisorn Ratanayotha
Osaka University
Read the Original
This page is a summary of: Molecular and functional characterization of the voltage‐gated proton channel in zebrafish neutrophils, Physiological Reports, August 2017, Wiley,
DOI: 10.14814/phy2.13345.
You can read the full text:
Resources
Contributors
The following have contributed to this page
