What is it about?
BMP7 exerts its action in a dose-dependent fashion. BMP7 stimulates proliferation at low to intermediate concentration in the periphery of the fetal kidney, whereas induces cadherin-11 expression at intermediate concentration near the tip of ureteric bud thereby stimulating cap mesenchyme formation.
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Why is it important?
We found the dose-dependent effect of BMP7 and its signaling in metanephric mesenchymal cells. Furthermore, the role of cadherin-aa, an adhesion molecule, in stimulating cap mesenchyme formation was demonstrated.
Perspectives
This study will hopefully stimulate the future investigation on the role of cadherin-11 in kidney development, especially in nephron progenitor cells as well as signaling pathways of BMP7 other than MAP kinase.
Midori Awazu
Keio Gijuku Daigaku
Read the Original
This page is a summary of: BMP7 dose‐dependently stimulates proliferation and cadherin‐11 expression via ERK and p38 in a murine metanephric mesenchymal cell line, Physiological Reports, August 2017, Wiley,
DOI: 10.14814/phy2.13378.
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