What is it about?
In this review, we seek to highlight the classic roles of cytokines in osteosarcoma, to describe the role of new players in the emerging cytokine networks, and to discuss the therapeutic targets that encompass the complexity and implications of this network.
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Why is it important?
Osteosarcoma is the most prevalent primary bone cancer. Although it has a global impact of approximately 1 to 3 cases/million a year, its etiopathophysiology is still unknown. Moreover, the immune response to its development is very individual as well as variable. Particular emphasis has been placed on the study of the immunoregulatory role of cytokines in osteosarcoma. In this scenario, newly identified cytokine networks have emerged.
Perspectives
A deep understanding on the complex interplay of cytokines in osteosarcoma may have prognostic importance.
Dr Luís Carlos Lopes-Júnior
Federal University of São Carlos - UFSCar
Read the Original
This page is a summary of: EMERGING CYTOKINE NETWORKS IN OSTEOSARCOMA, Cancer Cell & Microenvironment, February 2017, Smart Science and Technology, LLC,
DOI: 10.14800/ccm.1510.
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