What is it about?
Combination therapy with TOF plus intensive GMA was well tolerated and may be useful for induction of clinical remission in patients with refractory UC.
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Why is it important?
The use of monotherapy with intensive granulocyte and monocyte adsorptive apheresis (GMA) or a Janus kinase (JAK) inhibitor has been limited to patients with refractory ulcerative colitis (UC). The efficacy and safety of combination therapy with tofacitinib (TOF) plus intensive GMA (two sessions per week) for refractory UC have not been evaluated. This study firstly showed the 10-week efficacy of combination therapy with TOF plus intensive GMA in patients with refractory UC.
Perspectives
It has been proposed that combination therapy with TOF plus intensive GMA may be useful and one of therapeutic options for induction of clinical remission in patients with refractory UC.
Dr Satoshi Tanida
Nagoya City university
Read the Original
This page is a summary of: Combination Therapy With Tofacitinib Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis as Induction Therapy for Refractory Ulcerative Colitis, Journal of Clinical Medicine Research, January 2020, Elmer Press, Inc.,
DOI: 10.14740/jocmr4037.
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