What is it about?

Status epilepticus (SE) is a life-threatening neurological emergency that requires immediate medical intervention, and is associated with high mortality and morbidity. Refractory status epilepticus (RSE) is a more severe variant of SE. We studied 50 children admitted with us with SE, to determine how many progressed to RSE, and the associated factors.

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Why is it important?

Twenty children with SE (40%) progressed to RSE. Central nervous system (CNS) infection was the most common etiology (53% in SE and 55% in RSE, p > 0.05). Non-compliance with anti-epileptic drugs was the second most common etiology. The overall mortality rate was 38%. The odds of having a poor outcome was six times higher in children with RSE as compared to those with SE [OR (95% CI)=6.0 (1.6-22.3); p = 0.005].


When managing CNS infections, pediatricians need to be aware of the high risk of developing RSE. In addition, the possibility of RSE should be considered and managed promptly in an intensive-care setting, to reduce the mortality and morbidity of this severe neurological condition

Dr Devendra Mishra
Maulana Azad Medical College

Read the Original

This page is a summary of: Clinico-Etiological Profile of Pediatric Refractory Status Epilepticus at a Public Hospital in India, Journal of Epilepsy Research, June 2019, Korean Epilepsy Society,
DOI: 10.14581/jer.19004.
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