Endometrial tissue and fluid harbor different bacteria
What is it about?
The microbiota in the endometrial fluid of patients receiving in vitro fertilization (IVF) treatment has been shown to be useful for predicting pregnancy rates, but whether it reflects the microbiota in the endometrial tissue remains obscure. To address this, we profiled simultaneously the microbiotas in the endometrial fluid and biopsy samples of IVF patients using massively parallel sequencing. We identified bacterial taxa that were consistently detected only in endometrial biopsies but not in fluid samples, and taxa that were differentially abundant between these two sample types. Profiling both fluid and biopsy samples will reveal a more comprehensive view of the endometrial microbiome.
Why is it important?
Our data suggest that microbiota in the endometrial fluid does not fully reflect that in endometrial tissue. Sampling from both endometrial fluid and biopsy allows a more comprehensive view of microbial colonization.
The following have contributed to this page: Stephen Chim and Yingyu Liu