What is it about?
. MO ameliorated DOX-induced oxidative stress as evidenced by decreasing lipid peroxidation, protein oxidation and total oxidant capacity depletion and by increasing antioxidant capacity. Additionally, MO pretreatment inhibited inflammatory responses to DOX by decreasing the expressions of nuclear factor kappa-B, tumor necrosis factor-alpha and cyclooxygenase-2 and the activity of myeloperoxidase. MO ameliorated DOX-induced apoptotic tissue damage in heart of rats. In vitro study showed that MO augmented the anticancer efficacy of DOX in human breast cancer cells (MCF-7) and potentiated oxidative damage and apoptosis. Thus, combination of DOX and MO may prove future cancer treatment protocols safer and more efficient.
Featured Image
Why is it important?
Our study provides evidences for the promising ameliorating effects of MO against DOX-induced cardiotoxicity in rats through modulation of oxidative stress, diminution of inflammation and abrogation of apoptosis in rat heartMO may be beneficial for DOX-induced cardiotoxicity. This, however, needs to be confirmed in a more clinically relevant model to elucidate the mechanism and develop strategies in prevention against DOX-induced cardiotoxicity.
Perspectives
Identification of a mechanism for MO anticancer effect introduces the possibility that combining this plant with DOX might enhance the therapeutic efficacy of DOX in clinical oncology. Beneficial effect of the MO extract is likely due to the synergistic interactions of phenolic compounds and other triterpene acids of MO. Accordingly, this study provides new insights into the development of strategies to augment anticancer activity of DOX and further to alleviate its cardiotoxicity. Further confirmatory studies both at preclinical and clinical levels are needs to evaluate a combination therapy.
Dr Alaaeldin A Hamza
National Organization for Drug Control and Research
Read the Original
This page is a summary of: Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells, PLoS ONE, November 2016, PLOS,
DOI: 10.1371/journal.pone.0167049.
You can read the full text:
Contributors
The following have contributed to this page
