What is it about?
Influenza is a common viral pathogen with costly impacts for both humans and livestock. To better understand the immune response to influenza, we have produced a single-cell resolution map of genes expressed by immune cells during influenza infection and different vaccination strategies. Using this gene map we have identified long lasting and varied effects to infection versus vaccination, whilst also providing an extensive resource for further investigation of the immune response to influenza.
Featured Image
Photo by National Institute of Allergy and Infectious Diseases on Unsplash
Why is it important?
Improving our understanding of the immune response to influenza provides insights that can inform better vaccine design to achieve long-lasting protective immune responses. Furthermore, by making our data freely available we hope it will serve as a resource for further scientific advancement.
Read the Original
This page is a summary of: Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunization in the pig lung, PLoS Pathogens, July 2024, PLOS,
DOI: 10.1371/journal.ppat.1011910.
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Resources
Project Github
All code used for processing and analysis of scRNA-seq data in this study.
Data Repository
Repository of all scRNAseq data generated during this study.
Babraham Institute News Article
Babraham Institute news article commemorating the study publication.
Pirbright Institute News Article
Pirbright Institute news article commemorating study publication.
Contributors
The following have contributed to this page