Fis regulates genes essential for disease in P.multocida

What is it about?

P.multocida is a bacterium that causes fowl cholera (an economically important disease of chickens and turkeys). In this paper, we identify a gene (fis) that regulates virulence genes, including those responsible for the production of capsule (which protects the bacterium from the host immune system).

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Why is it important?

If you know how genes that cause disease are controlled, it may be possible to develop a vaccine that targets the regulator.