What is it about?

Vitamin D concentrations are largely affected by sunlight exposure. It has been hypothesized but seldom tested that the winter excess in cardiovascular disease is related to hypovitaminosis D. In this study, which included almost 80,000 participants from eight European cohorts, we have conducted a detailed analysis on the association between seasonal changes in vitamin D and seasonal changes in cardivascular disease outcomes.

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Why is it important?

Our study adds important perspectives to the existing literature on the association between vitamin D and cardiovascular disease, providing no support for the long-standing hypothesis that the winter excess in cardiovascular disease is due to short-term reductions in vitamin D.

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This page is a summary of: Cardiovascular disease outcomes in relation to 25-hydroxyvitamin D and its seasonal variation: Results from the BiomarCaRE consortium, PLOS One, April 2025, PLOS,
DOI: 10.1371/journal.pone.0319607.
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