What is it about?

The ultimate goal of any disease treatment plan is to achieve the optimum therapeutic outcomes and improve patients’ quality of life avoiding additional harm. Although pharmacological therapies are considered crucial for the management of diseases, these might be associated with treatment-related problems (TRPs). These are known as events or circumstance associated with the patient management that can actually or possibly impede the ability to attain the defined goals of treatment. Unresolved TRPs can increase morbidity and mortality, reduce the patients’ quality of life, increase emergency department and outpatient clinic visits, prolong the length of hospital stay and increase the economic burden on healthcare systems.

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Why is it important?

Despite TRPs have been widely investigated, evidences remain scarce among patients with COPD, particularly during exacerbation requiring hospital admission. Among the middle east and north Africa region, Jordan had the second-highest COPD prevalence with a rate of 5.4%. Despite this, there is lack of clinical research among these patients in general, with no studies ever investigating the burden of AECOPD in particular. This study aimed to assess and categorize TRPs among patients’ cases hospitalized with AECOPD in Jordan, and to estimate their potential cost saving and cost avoidance.


This is one of the few studies investigating the TRPs and their cost among patients with AECOPD. Several TRPs were identified among the study participants representing a concern for patients’ safety and an important impact on healthcare system expenditure. This implicate the implementation of interventions such as embracing the role of clinical pharmacists in the respiratory care units to optimize the patients’ management.

Haya Tabaza
University of Jordan

Read the Original

This page is a summary of: Acute COPD exacerbations and in-hospital treatment-related problems: An observational study, PLoS ONE, June 2024, PLOS,
DOI: 10.1371/journal.pone.0305011.
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