What is it about?
The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S. mutans is involved in the pathogenesis of IgAN remains unclear. The present study evaluated glomerular galactose-deficient IgA1 (Gd-IgA1) to clarify the association between the presence of cnm-positive S. mutans and glomerular Gd-IgA1 in patients with IgAN.
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Why is it important?
There was a significant association between the glomerular staining intensity of Gd-IgA1 (KM55) and the positive rate of cnm-positive S. mutans.
Perspectives
Our present findings are consistent with the new concept of an oral–kidney association and could establish a new treatment for IgAN. Considering that S. mutans is a pathogen that causes dental caries, reducing it in the oral cavity to prevent dental caries may improve the prognosis of IgAN.
Taro Misaki
Seirei Hamamatsu General Hospital
Read the Original
This page is a summary of: cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy, PLoS ONE, March 2023, PLOS,
DOI: 10.1371/journal.pone.0282367.
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