What is it about?

The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S. mutans is involved in the pathogenesis of IgAN remains unclear. The present study evaluated glomerular galactose-deficient IgA1 (Gd-IgA1) to clarify the association between the presence of cnm-positive S. mutans and glomerular Gd-IgA1 in patients with IgAN.

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Why is it important?

There was a significant association between the glomerular staining intensity of Gd-IgA1 (KM55) and the positive rate of cnm-positive S. mutans.


Our present findings are consistent with the new concept of an oral–kidney association and could establish a new treatment for IgAN. Considering that S. mutans is a pathogen that causes dental caries, reducing it in the oral cavity to prevent dental caries may improve the prognosis of IgAN.

Taro Misaki
Seirei Hamamatsu General Hospital

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This page is a summary of: cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy, PLoS ONE, March 2023, PLOS, DOI: 10.1371/journal.pone.0282367.
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