GSDMB may play a role in the pathogenesis of psoriasis.

What is it about?

Gasdermin (GSDM) B is is a protein that may be involved in the cell pyroptosis process. It is reported to be associated with inflammatory diseases. However, the correlation between GSDMB and psoriasis vulgaris is not clear. In our study, the level of GSDMB protein in the skin lesions of patients with psoriasis vulgaris was detected. We establish a cell model with low GSDMB gene expression through interfering sequence siRNA, and measured the mRNA and protein expression levels of the GSDMB before and after gene silencing. The cell viability and cell apoptosis was also detected. We found the lower level of GSDMB protein in the skin lesions of patients with psoriasis vulgaris than that in normal skin tissues, the lower mRNA and protein expression levels in GSDMB silencing group, and the decreased proliferation and increased apoptosis of HaCaT cells in the cell model. As is reported that overdevelopment of keratinocytes toward differentiation inhibits their own proliferation, we believe that down-regulation of GSDMB expression can inhibit cell proliferation and promote cell apoptosis. We speculate that GSDMB may play a role in the pathogenesis of psoriasis by affecting the differentiation of keratinocytes.

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Photo by Alberto Rudolphi on Unsplash

Photo by Alberto Rudolphi on Unsplash

Why is it important?

Our findings show that down-regulation of GSDMB expression can inhibit cell proliferation and promote cell apoptosis. Thus we speculate that GSDMB may play a role in the pathogenesis of psoriasis by affecting the differentiation of keratinocytes.

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