What is it about?

The goal in appendicitis is early diagnosis and early treatment. Therefore, there is a need for fast, low-cost markers that can be diagnosed earlier. The immature granulocyte test is thought to be one of these markers. In our study, it was aimed to evaluate effectiveness of immature granulocyte (IG) count and IG ratio (IG%), in distinguishing complicated and simple acute appendicitis.

Featured Image

Why is it important?

Our study shows that the IG count is a strong negative predictive test for acute appendicitis disease, that is this finding allows to differentiate those without acute appendicitis. As well as it is more predictive value than the other cell blood count (CBC) tests for acute complicated appendicitis. If the IG count is differentiated from simple appendicitis and complicated appendicitis, non-operative treatment approaches can be performed.


Immature granulocytes are premature granulocytes (promyelocyte, myelocyte, metamyelocyte) released from the bone marrow when there is infection, inflammation, sepsis, and other stimuli. It can be counted by IG count analysis. And IG count is a fast, strong and inexpensive test method. It can play an important role in early diagnosis in other diseases besides appendicitis. So medical device companies should develop this analyzing and pay attention to it.

Gulsum Feyza Turkes

Read the Original

This page is a summary of: Predictive value of immature granulocyte in the diagnosis of acute complicated appendicitis, PLoS ONE, December 2022, PLOS, DOI: 10.1371/journal.pone.0279316.
You can read the full text:



The following have contributed to this page