What is it about?
Interleukins are typically produced by immune cells that can 'talk' to surrounding cells in tissues and influence their behavior. This paper shows that interleukins 4 and 13 'talk' to prostate fibroblasts and cause them to secrete collagen proteins, which promotes fibrosis and prostatic dysfunction.
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Why is it important?
Lower urinary tract dysfunction (LUTD) is a costly and pervasive medical problem for millions of aging men. Prostatic fibrosis is increasingly recognized as a major cause of LUTD, such as urinary voiding problems. However, no therapeutics are in clinical use to directly treat lower urinary tract fibrosis. This paper shows that interleukin communication pathways through JAK/STAT signaling is a promising therapeutic target to treat lower urinary fibrosis and consequent urinary voiding dysfunction.
Read the Original
This page is a summary of: The IL-4/IL-13 signaling axis promotes prostatic fibrosis, PLoS ONE, October 2022, PLOS, DOI: 10.1371/journal.pone.0275064.
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