What is it about?
Many reports have shown that sarcopenia strongly correlated with a poor prognosis. However it is unknown whether sarcopenia increases lung cancer recurrence. This study was to evaluate whether sarcopenia directly increases recurrence and whether it suppresses anti-tumor immunity in patients with lung cancer.
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Why is it important?
The 5-year recurrence rate in patients with sarcopenia was significantly higher than those without sarcopenia. Tumor immunity in saccopenia patients have rich in tumor-associated macrophages which promote tumor progression and metastasis.
Perspectives
Our findings indicate the need for future translational research to clarify the biological interaction between sarcopenia and regulation of cancer immunity.
Yo Kawaguchi
Shiga Ika Daigaku
Read the Original
This page is a summary of: Sarcopenia increases the risk of post-operative recurrence in patients with non-small cell lung cancer, PLoS ONE, September 2021, PLOS,
DOI: 10.1371/journal.pone.0257594.
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