What is it about?

Improving Intravoxel Incoherent Motion (IVIM) imaging for better measurements about perfusion in human body. We use simulations with general linear model and Cramér-Rao Lower Bounds techniques to find acquisition parameter which provide smallest standard deviation into perfusion parameter maps.

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Why is it important?

Based on thorough analysis for acquisition parameters, we suggest optimal b-values to be used in brain IVIM. We make comparison of between various suggested b-value settings for IVIM, using permutations of 16 b-values during 1-hour long scanning session with four volunteers. We found that physiological noise at low b-values and thermal noise at high b-values propagates to parameter maps.


We suggest using more signal averaging at low b-values, as they seem to affect more to D* perfusion parameter which is most noisy of IVIM model parameters.

Harri Merisaari
University of Turku

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This page is a summary of: Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain, PLoS ONE, September 2021, PLOS, DOI: 10.1371/journal.pone.0257545.
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